7/28/2021: CDC Updated STI Treatment Guidelines


Dear Colleagues,

CDC has released Sexually Transmitted Infections Treatment Guidelines, 2021. This document provides current evidence-based diagnostic, management, and treatment recommendations, and serves as a source of clinical guidance for managing sexually transmitted infections (STIs).


The new guidelines include notable updates from the previous 2015 guidance, including:

  • Updated treatment recommendations for chlamydia, trichomoniasis, and pelvic inflammatory disease.
  • Updated treatment recommendations for uncomplicated gonorrhea in neonates, children, and other specific clinical situations (e.g., proctitis, epididymitis, sexual assault), which builds on broader treatment changes published in Morbidity and Mortality Weekly Report late last year.
  • Information on FDA-cleared diagnostic tests for Mycoplasma genitalium and rectal and pharyngeal chlamydia and gonorrhea.
  • Expanded risk factors for syphilis testing among pregnant patients.
  • Recommended two-step serologic testing for diagnosing genital herpes simplex virus.
  • Harmonized recommendations for human papillomavirus vaccination with the Advisory Committee on Immunization Practices.
  • Recommended universal hepatitis C testing in alignment with CDC’s 2020 hepatitis C testing recommendations.


You can stay informed on the latest STI recommendations and clinical guidance with CDC’s online and print resources, which include:

  • An updated wall chart and pocket guide summarizing the current treatment and screening recommendations. A limited number of free copies will be available for order through CDC-INFO On Demand in the coming weeks, as well as the MMWR PDFs are available online in the meantime.
  • An updated STI Treatment Guidelines mobile app is in development and is expected to launch in the coming months. NOTE: The 2015 STD Treatment Guidelines app will be retired at the end of July 2021. CDC is finalizing an interim, mobile-friendly solution – please visit STI Treatment Guidelines (cdc.gov) where we will post information, as it becomes available.
  • A customizable letter is also available for colleagues looking to promote the updated guidelines.

CDC partners offer an array of additional resources. The National Network of STD Clinical Prevention Training Centers provides training and technical assistance. Providers also can access STD clinical consultation services through the latest STD Clinical Consultation Network.


For questions about the updated 2021 STI Treatment Guidelines, email the Clinical Team in CDC’s Division of STD Prevention at stitxguidelines@cdc.gov.


Yakima Health District STI testing services are available Wednesdays from 8:30-4:00, no appointment necessary. For additional questions please call 509-575-4040.