Amebic meningitis
Anthrax
Botulism (foodborne, wound, infant)
Burkholderia mallei (Glanders) and pseudomallei (Melioidosis)
Cholera
Coronavirus infection (SARS, MERS, COVID-19)
Diphtheria
Domoic acid poisoning (amnesic shellfish poisoning) 
Haemophilus influenzae (invasive disease) (children under 5 years old)
Influenza (novel or unsubtypable strain)
Measles (rubeola) (acute)
Meningococcal disease (invasive)
Mpox
Outbreak (suspected foodborne or waterborne origin) 
Paralytic shellfish poisoning

Pesticide poisoning (hospitalized, fatal, cluster)—Call (800) 222-1222.
Plague
Poliomyelitis
Rabies (confirmed human or animal) (suspected human exposure)
Rubella (including congenital rubella syndrome) (acute)
Shiga toxin-producing E. coli infections (including but not limited to E. coli O157:H7) 
Smallpox
Suspected institutional outbreak of any illness (e.g., influenza-like illness, gastro-intestinal symptoms)
Tularemia
Vaccinia transmission
Viral hemorrhagic fever
Yellow fever

Baylisascariasis
Brucellosis
Candia auris infection or colonization
Hantaviral infection
Hepatitis A (acute)
Hepatitis B (acute)
Hepatitis C (acute)
Hepatitis C (perinatal)
Hepatitis D (acute or chronic)
Hepatitis E (acute)

Legionellosis
Leptospirosis
Listeriosis
Mumps (acute)
Pertussis
Psittacosis
Q fever
Salmonellosis
Shigellosis
Tuberculosis (confirmed or highly suspicious)

Vancomycin-resistant
Staphylococcus aureus (not vancomycin-intermediate)
Vibriosis
Yersiniosis
Unexplained critical illness or death

Acquired immunodeficiency syndrome (AIDS) (including people previously reported with HIV)
Anaplasmosis 
Arboviral disease (acute) (including, but not limited to, chikungunya, dengue, eastern and western equine encephalitis, Japanese encephalitis, LaCrosse encephalitis, Powassan virus, St. Louis encephalitis, West Nile virus, Zika virus)
Babesiosis
Campylobacteriosis
Carbapenem-resistant Enterobacteriaceae infections (limited to Klebsiella species, E. coli, Enterobacter species)
Chagas disease
Chancroid
Chlamydia trachomatis infection
Coccidioidomycosis

Cryptococcus gattii or undifferentiated Cryptococcus species (e.g., Cryptococcus not identified as C. neoformans)
Cryptosporidiosis
Cyclosporiasis
Cysticercosis 
Echinococcosis 
Ehrlichiosis 
Giardiasis
Gonorrhea
Granuloma inguinale
Hepatitis B surface antigen positive pregnant women
Hepatitis B (chronic) (initial diagnosis and previously unreported cases)
Hepatitis B (perinatal) (initial diagnosis) 
Hepatitis C (chronic)
Herpes simplex (neonatal and genital) (initial diagnosis)
Histoplasmosis 
HIV infection

Human prion disease Immunization reactions (severe, adverse)
Influenza-associated death (lab confirmed)
Lyme disease
Lymphogranuloma venereum
Malaria
Pesticide poisoning (non-hospitalized, non-fatal, non-cluster)—Call (800) 222-1222.
Relapsing fever (borreliosis)
Rickettsia infection 
Syphilis (including congenital)
Taeniasis 
Tetanus
Tick paralysis 
Trichinosis
Typhus 
Varicella-associated death

Tuberculosis infection (latent) (positive tuberculosis skin test or interferon-gamma release assay, e.g., QuantiFERON^®-TB Gold)

Asthma (occupational) (suspected or confirmed)—Call (888) 66-SHARP.
Birth defects (autism spectrum disorders, cerebral palsy, alcohol-related)—Call (360) 236-3533.